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Leica - Supporting you with your COVID-19 research
As the novel human respiratory coronavirus COVID-19 continues to expand globally, there is an increasing need to develop therapies to alleviate and ultimately stop this pandemic.
Following are the recent publications related to COVID-19 where Leica Microsystems have been used for your reference to find optimal workflow solutions for your research so that you can gain the insights you need.
1) Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
This publication shows that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, the imaging was done using a Leica SP5 - even of the organoids.
Highlights of the publication are:
- Soluble human ACE2 can inhibit SARS-CoV-2 infections
- SARS-CoV-2 can directly infect human blood vessel and kidney organoids
- Human organoids as model systems to study SARS-CoV-2 infections/COVID-19
2) Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
These publications show the co-localization of the SARS-CoV-2 with the main receptor it is proposed to bind with, Confocal imaging is done using the Leica SP8.
Highlights are:
- SARS-CoV-2 interacts with hACE2 via S protein CTD
- A 2.5-A? structure of SARS-CoV-2-CTD in complex with hACE2 is resolved
- The SARS-CoV-2-CTD displays a stronger affinity for hACE2 compared with SARS-RBD
- SARS-CoV-2 -CTD is antigenically different from SARS-RBD
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